Our new Obvious+ tissue clearing procedure is the only real method that delipidates samples with no modify in morphology and with nominal influence on structural integrity.
Megatome is usually a vibrating microtome built to section a broad selection of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With large blade vibrating frequency and minimized blade deflection, Megatome allows substantial-throughput tissue sectioning with uniform floor profile, and negligible tissue damage and information loss.
Antibodies could just take weeks to diffuse via only a few millimeters of tissue, with a steep labeling gradient from surface to core.
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SE employs a rotational electrical area to disperse very electromobile molecules (including antibodies or surfactant micelles) all through a porous sample with out damaging electrically billed buildings in the tissue. This enables 2-four working day clearing of intact organs,
Our preformulated EasyIndex Answer raises and homogenize the refractive index of delipidated tissue samples, rendering them fully clear. This permits mild penetration into the sample and makes sure the acquisition of substantial-resolution, in-target image details.
Megatome can be a novel microtome that allows for top-precision sectioning of an array of tissue samples – from organoids, to arrays of animal organs, to intact human brain hemispheres – with small tissue harm and knowledge reduction.
eFLASH is a swift tissue labeling approach that allows for uniform complete-organ staining in 20 rounds of labeling.
The SmartSPIM light sheet microscope delivers unparalleled resolution and acquisition pace all over intact tissue megatomi.com volumes, although its modular structure lets you upgrade and personalize individual parts.
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Protect avoids the variability of hydrogel embedding and the knowledge decline from PFA preservation, guarding specimens for a number of rounds of processing.
Leverage the Clear+ tissue clearing technique, as well as eFLASH and patented stochastic electrotransport systems, to fast distinct and label entire organs. Essential highlights and options include:
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